Is there any way we can search for TWO Performer names together ie Sandler & Barrymore, or compare two casts side-by-side ie Sequels

Yup.
Advanced Search, Collaborations.

Lots of options available.

Here's a starting point for you:

https://www.imdb.com/search/title/?role=nm0001191,nm0000106

And here's a relevant Help article:

Using the Advanced Search feature

Contents: What is Advanced Search? How do I use Advanced Search? - titles & people | collaborations | topics What is Advanced Search? IMDb lists millions of different titles, of many varying types (e.g., movies, episodic series, vi ... Read more.