Live Poll: Best Duo Synergy in TV Series

I'm going for how good they are as actors and characters together and how central they were for their shows, not how good friends the characters are. But I guess it's up to the poll author to define.

Maybe synergy is not the correct word. With this poll, I was going for mihailo.razvigor's point, a pair or a duo that, independently of their good intentions or good relationship, they just make damn good entertainment for us viewers.
I have as an example Ragnar and King Ecbert, from Vikings. They are barely on screen together, but when they are I just keep asking for more (that's a personal perspective).
So after this trend of comments, I'm left with two questions:
Should I change the title, and put Chemistry instead of Synergy?
I never watched Frasier, so I don't have an opinion on that, but regarding Breaking Bad, I personally didn't like Walter and Jesse together; so, should I add both the duos from Frasier and Breaking Bad, only one or none?

In the meantime, I'm adding Mulder and Scully (:

Frasier would have been just as good if he had no brother.
Breaking Bad would have been just as good if Walter had no partner.

Hot take!

You are free to think the shows would be as good without some of their most central parts, but I think in both cases the interactions between those characters are one of the most popular aspects of the shows.

I second Niles and Frasier and especially Walter White and Jesse. 

Hi ruby, thank you, I'm happy to be back (:

I added your suggestions to the list, as well as the two suggestions from the other comment, thank you for your tiebreaker :D